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SENSATES AND THEIR APPLICATION IN CONSUMER PRODUCTS A. INTRODUCTION There is considerable interest in the use of sensates in consumer products (including pharmaceutical products). When consumed as part of a food or beverage or applied bucally, nasally or dermally, they can deliver cooling, warming, tingling, pungency or other desirable or beneficial sensorial effects to products containing them. Sensates are widely used in consumer products not only because of the interesting organoleptic properties they can deliver, such as cooling, warming, tingling or pungen- cy. Although they are for the most part tasteless and odourless, nevertheless they can also be used to modulate the taste and aroma of consumer products, or even contrib- ute to the perception of other organoleptic effects, such as juiciness, deliciousness, freshness and sweetness. They can also be employed to mask unwanted organoleptic effects, such as bitterness or astringency. They are also employed in dermal applications, such as in cosmetics and toiletries, to provide cooling, warming, and other organoleptic effects, such as soothing, calming and refreshing effects, to the skin or scalp. They can also create a perception of moisturization and hydration. B. SENSATE COMPOUNDS Examples of a novel class of sensate compounds, particularly valued for their cooling effect are selected from the following compounds: 2-(methylthio)-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one; 2-(methylthio)-1-(2-(5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1- yl)propan-1-one; 2-(ethylthio)-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1- yl)propan-1-one; 2-methyl-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)but-3-en- 1-one; 2-methyl-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)butan-1-one; (R)-2-(methylthio)-1-((R)-2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1- one; (2S)-2-methyl-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)butan-1-one; 2-methyl-2-(methylthio)-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1- one; 2,2-dimethyl-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)but-3-en-1-one; 2-(methylthio)-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl)propan-1-one oxa- late; 1-isopropyl-3,3,5,7-tetramethyloctahydrobenzo[c]isoxazole; 5-(4-fluorophenyl)- 1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole (including (3aR,5R,7S,7aR)-5-(4- fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole; (3aR,5R,7R,7aR)-5- (4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole; and (3aR,5R,7S,7aS)-5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo [c]isoxazole); and mixtures thereof. Any of the aforementioned sensates are particularly preferred materials that can be used in consumer products in combination with the various ingredients described hereinbelow. Older, but commercially well-known sensates are selected from N-substituted p- menthane carboxamides. Particularly important compounds include N-(4- cyanomethylphenyl) p-menthanecarboxamide, N-(4-sulfamoylphenyl) p- menthane- carboxamide, N-(4-cyanophenyl) p-menthanecarboxamide, N-(4-acetylphenyl) p- menthanecarboxamide, N-(4-hydroxymethylphenyl) p-menthanecarboxamide, N-(3- hydroxy-4- methoxyphenyl) p-menthanecarboxamide, or mixtures thereof. N-(4-cyanomethylphenyl) p-menthanecarboxamide is commercially available from Givaudan under the trade name EverCool™ 180. Other important N-substituted p-menthane carboxamides include menthone glycerol acetal (for example, sold as Frescolat® MGA by Haarmann & Reimer), N-(4- cyanomethylphenyl)-ρ-menthanecarboxamide or N-(4-cyanomethylphenyl)-5-methyl- 2-(1-methylethyl)cyclohexanecarboxamide (for example, commercially available from Givaudan), N-(2-(pyridin-2-yl)ethyl-3-ρ-menthanecarboxamide (for example, com- mercially available from Givaudan), N-(4-sulfamoylphenyl)-ρ-menthanecarboxamide, N-(4-cyanophenyl)-ρ-menthanecarboxamide, N-(4-acetylphenyl)-ρ- menthanecarboxamide, N-(4-hydroxymethylphenyl)-ρ-menthanecarboxamide, N-(3- hydroxy-4-methoxyphenyl)-ρ-menthanecarboxamide, 2-Isopropyl-N,2,3- trimethylbutyramide (for example, known as WS-23); N-Ethyl-ρ-menthane-3- carboxamide (for example, known as WS-3); Ethyl 3-(ρ-menthane-3- carboxamido)acetate (for example, known as WS-5), menthyl lactate (for example, commercially available as Frescolat® ML by Haarmann & Reimer), Menthoxypropane- 1,2-diol (for example, commercially available as Coolant Agent 10 by Takasago Inter- national), ρ-Menthane-3,8-diol (for example, commercially available as PMD38)- Takasago International, Isopulegol (for example, commercially available under the name “Coolact P®” by Takasago International), (1R,2S,5R)-2-isopropyl-5-methyl-N- (2-(pyridyn-2-yl)ethyl)cyclohexane-1-carboxamide (commercially available from Givaudan under the trade name EVERCOOL 190), (1-glyceryl-p-mentane-3- carboxylate), (ethyleneglycol-p-methane-3-carboxylate), (N-t-butyl-p-menthane-3- carboxamide), (N-(4-,ethoxyphenyl)-p-menthane-3-carboxamide), 3-(1- menthoxy)propane-1,2-diol, 3-(1-Menthoxy)-2-methylpropane-1,2-diol, menthyl pyr- rolidone carboxylate) (for example, commercially available as Questice®), (1R,3R,4S)- 3-menthyl-3,6-dioxaheptanoate (for example, commercially available from Firmenich), (1R,2S,5R)-3-menthyl methoxyacetate (for example, commercially available from Firmenich), (1R,2S,5R)-3-menthyl 3,6,9-trioxadecanoate (for example, commercially available from Firmenich), (1R,2S,5R)-menthyl 11-hydroxy-3,6,9-trioxaundecanoate (for example, commercially available from Firmenich), (1R,2S,5R)-3-menthyl (2- hydroxyethoxy)acetate (for example, commercially available from Firmenich), Cubebol (for example, commercially available from Firmenich), 1-[2-hydroxyphenyl]-4-[2- nitrophenyl-]-1,2,3,6-tetrahydropyrimidine-2-one), 4-methyl-3-(1-pyrrolidinyl)-2[5H]- furanone (for example, known as Icilin or AG-3-5), menthyl lactate, menthone glycer- in acetal, L-Monomenthyl succinate, L-monomenthyl glutarate, 3-1-menthoxypropane- 1,2-diol (for example, known as Coolact 10), 2-1-menthoxyethanol (for example, known as Cooltact 5), and mixtures thereof. Additional non-menthol coolants are described in U.S. Pat. No. 7,414,152, US20100086498 A1 and WO2010/128026 A2, which coolants are incorporated herein by reference. Other sensates useful as cooling agents are disclosed in U.S. Pat. Nos. 4,136,163 and 4,150,052 and 4,178,459 and 4,190,643 and 4,193,936 and 4,226,988 to Watson et al., U.S. Pat. Nos. 4,230,688 and 4,032,661 and 4,153,679 and 4,296,255 to Rowsell et al., U.S. Pat. No. 4,459,425 to Amano et al., U.S. Pat. No. 5,009,893 to Cheruki et al., U.S. Pat. No. 5,266,592 to Grub et al., U.S. Pat. No. 5,698,181 to Luo, U.S. Pat. Nos. 5,725,865 and 5,843,466 to Mane et al., U.S. Pat. No. 6,231,900 to Hanke, U.S. Pat. No. 6,277,385 to Luke, U.S. Pat. Nos. 6,280,762 and 6,306,429 and 6,432,441 to Bealin Kelly et al., U.S. Pat. Nos. 6,455,080 and 6,627,233 and 7,078,066 to Wolf et al., U.S. Pat. No. 6,783,783 to Clark et al., U.S. Pat. No. 6,884,906 to Dewis et al., U.S. Pat. No. 7,030,273 to Sun, and U.S. Pat. No. 7,090,832 to Zanone et al.; U.S. patent application Publication Nos. U.S. 2004/0175489 of Clark et al., U.S. 2004/0191402 of Stawski et al., U.S. 2005/0019445 of Wolf et al., U.S. 2005/0222256 and U.S. 2005/0265930 of Erman et al., U.S. 2006/0159819 of Wit- kewitz et al., and U.S. 2006/0249167 of Giersch et al.; European Patent Application No. EP 1689256 A1 of Shimizu et al.; and International Patent Application Nos. WO 2005/082154 A1 of Johnson et al., WO 2005/099473 A1 of Vanrietvelde et al., WO 2006/058600 A1 of Foster et al., WO 2006/092076 A2 of Galopin et al., and WO 2006/125334 A1 of Bell et a...