Research Disclosure no longer supports Internet Explorer

CRYSTALLINE FORMS OF A COMPOUND Described herein are two crystalline forms (Form 1 and Form 2) of N-[(8R)-4-(1-methyl-2- oxo-1,2,3,4-tetrahydro-6-quinolinyl)-5,6,7,8-tetrahydro-8-isoquinolinyl]propanamide (referred to as Compound A herein). Methods of preparing Form 1 and Form 2 are described below. Compound A Compound A may be prepared by the methods disclosed in the International Patent Application published as WO2013/041591, e.g. according to Example 3-1. Preparation of Form 1 of Compound A A solution of Compound A (105 mol) in 1-propanol (200 L) was distilled (atmospheric pressure, constant volume by addition of further 1-propanol) until the water content of the solution was ≤0.15% w/w by Karl-Fischer titration. n-heptane (250 L) was added to the hot solution, and distilled (atmospheric pressure, constant volume by additi...